Sunday, March 31, 2013

End of the line for Roadrunner supercomputer

It's the end of the line for Roadrunner, a first-of-its-kind collection of processors that once reigned as the world's fastest supercomputer.

The $121 million supercomputer, housed at one of the nation's premiere nuclear weapons research laboratories in northern New Mexico, will be decommissioned Sunday.

The reason? The world of supercomputing is evolving and Roadrunner has been replaced with something smaller, faster, more energy efficient and cheaper. Still, officials at Los Alamos National Laboratory say it's among the 25 fastest supercomputers in the world.

"Roadrunner got everyone thinking in new ways about how to build and use a supercomputer," said Gary Grider, who works in the lab's high performance computing division. "Specialized processors are being included in new ways on new systems and being used in novel ways. Our demonstration with Roadrunner caused everyone to pay attention."

In 2008, Roadrunner was first to break the elusive petaflop barrier by processing just over a quadrillion mathematical calculations per second.

Los Alamos teamed up with IBM to build Roadrunner from commercially available parts. They ended up with 278 refrigerator-size racks filled with two different types of processors, all linked together by 55 miles of fiber optic cable. It took nearly two dozen tractor trailer trucks to deliver the supercomputer from New York to northern New Mexico.

The supercomputer has been used over the last five years to model viruses and unseen parts of the universe, to better understand lasers and for nuclear weapons work. That includes simulations aimed at ensuring the safety and reliability of the nation's aging arsenal.

As part of the U.S. nuclear stockpile stewardship program, researchers used Roadrunner's high-speed calculation capabilities to unravel some of the mysteries of energy flow in weapons.

Los Alamos has been helping pioneer novel computer systems for decades. In 1976, the lab helped with the development of the Cray-1. In 1993, the lab held the fastest supercomputer title with the Thinking Machine CM-5.

"And to think of where we're going to be in the next 10 to 15 years, it's just mindboggling," said lab spokesman Kevin Roark.

Right now, Los Alamos ? along with scientists at Sandia National Laboratories in Albuquerque and Lawrence Livermore National Laboratory in California ? is using a supercomputer dubbed Cielo. Installed in 2010, it's slightly faster than Roadrunner, takes up less space and came in at just under $54 million.

Roark said in the next 10 to 20 years, it's expected that the world's supercomputers will be capable of breaking the exascale barrier, or one quintillion calculations per second.

There will be no ceremony when Roadrunner is switched off Sunday, but lab officials said researchers will spend the next month experimenting with its operating system and techniques for compressing memory before dismantling begins. They say the work could help guide the design of future supercomputers.

? 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.

Source: http://feeds.nbcnews.com/c/35002/f/653377/s/2a2b3210/l/0L0Snbcnews0N0Ctechnology0Ctechnolog0Cend0Eline0Eroadrunner0Esupercomputer0E1C9144294/story01.htm

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Self Improvement | by Christine Maddox. | The Self Improvement Blog

PastBy Christine Maddox -

The past can help us make our future or it can hold us back from it. It can make us fear or make us bold. For most of us, however, it is overcoming our past that will lead to a brighter future. Unfortunately we were not raised by perfect people. Our parents were and are flawed human beings with their own baggage from the past. These generation issues have a tendency to stay in families for years and years and get passed down almost unconsciously. A short temper, physical abuse, lying, and more all end up becoming a daily part of our lives growing up. The bad thing is that most children never realize that their normal family lives are not normal at all. Things like being hit for trivial reasons or yelled at or just treated with indifference throughout childhood is not a healthy way to live, and yet many of us have grown up in those atmospheres and seem to expect the same thing from the rest of the world. Even though this is abuse in many ways, we are comfortable with it and thus chose to hang around and form relationships with people that are comfortable with it, mostly to our detriment.

The thing is that we need to let go of our past and redefine what normal and healthy is. We all have ways that we could live healthier lives. Maybe we see food as a reward and thus overeat; maybe we have bad self-images and feel ugly no matter what we do; or maybe we have short tempers and fly off the handle and expect others to be okay with it. Change is not easy but it is worth doing when you gain a new peace and hope in your future.

One of the major things that hold many people back from changing is the fact that you have to admit that you were wrong. That what you grew up in or used to do yourself was not healthy or normal. This can be a hard thing to deal with as no one likes to be wrong. It also implies that you have wasted your time or your life. This is not true. No matter how old you are you still have time to change and you owe it to yourself and those you love to make your life better.

I love a verse from the Bible that says, ?I will repay you for the years the locusts have eaten?? Joel 2:25a (NIV). I see those lost years spent in distress, anger or depression as years eaten by locusts. They are gone and behind us, and yet things can still be restored better than ever. Instead of focusing on what you have lost, look at what you have to gain. Living a healthy and balanced life is well worth the effort of confronting your past.

In my own life I have only begun the process of understanding what healthy living is like. My family has a long history of enabling and fostering helpless people who abuse those around them. There are two types of people, the givers and the takers. The givers are empty and hopeless because the takers take everything they have. The takers are resentful and abusive because they get everything without working for it and feel frustrated and useless.? This is a vicious cycle that has repeated itself generation after generation. Typically it is the women who are the givers and the men who are the takers.

Needless to say this does not foster healthy living conditions. As a child in this type of home I was raised to think in skewed ways. The men were helpless and had to be coddled and never expected to help out in any way beyond being employed, and sometimes not even then. The women were expected to be strong and productive and always loving no matter what the men did. They were supposed to work and take care of the children and the home with no outside help. In fact, from what I was exposed to I always wondered what the point of getting married was. It seemed much easier to just have kids and then get divorced. At least then you would get some money through child support and you wouldn?t have to deal with another big baby to take care of.

As I have gotten older I started to understand that this is not the way families or relationships that are healthy should work. Both parties should give and take equally and there should not be this cycle of sacrifice and greed. Letting go of my family?s idea of relationships actually made me want to find a partner of my own instead of staying single forever. Before I understood what a healthy relationship was I had decided to remain single and spare myself the pain. Now I understand what a blessing an equal partner can be.

Beyond just relational issues we also had issues with respect. Of course you can see where that comes in. How can you respect someone you are taking care of all the time, and how can someone be respected if they never set boundaries or limits? Learning to set proper boundaries without getting upset or frustrated is a process, but it is well worth doing. Having respect for yourself as well as others is very important in living a healthy and balanced life.

As you can see, I am still learning and growing. Overcoming your past is not a one-time thing. It takes a lot of effort and growth to move past what you have been exposed to and into a healthier future. But moving past the past is the only way to find a brighter future.

Author Bio:

This post is contributed by Christine Maddox. Currently she is pursuing her Master?s degree from the University of Texas as well as blogging for www.4nannies.com. She loves to write anything related to parenting, kids, nanny care etc. She can be reached via email at: christine.4nannies @ gmail.com.

?

Source: http://theselfimprovementblog.com/self-improvement/featured/pushing-past-the-past/

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Info Product Creation Tips | Internet Marketing Software, Tips And ...

Saturday, March 30th, 2013 at 3:30 pm ?

So you want to get into information product creation, good on you! So how the heck do you go about it? Fortunately It?s not quite as hard as you might imagine and believe me opportunity is everywhere! Every time that you spend money think of it as a way of making more money.

If you go to a conference network with people, maybe when you?re speaking to these people you will learn something that will in turn benefit others. Whatever you do look for opportunity, think of every time that you spend money as an opportunity to make more money. There is a product to be made from every experience, if you have learned something then you can share that information with other people and they will willingly pay you for it. Knowledge and experience are in invaluable asset. I?m a lover of automation and am always looking for ways to make my life easier and what benefits me will help other people too. You need to get into this mindset, there is a product to be made from every experience.

Look for opportunities on forums

Explore forums within your niche, do searches for terms like ?How do I?? and ?How to? you can make these searches broad or you can incorporate a specific keyword.

Try typing the following query into Google ?site:warriorforum.com ?How do I?+ list building. These kind of queries we?ll give you a basic foundation for research. Use the information you find to create products, it really doesn?t get much easier. I Have made tools specifically for this purpose just check out?Forum Renegade?and?Niche Generator. With these tools I have automated search process, it makes my life easier as it will yours.

Expert interviews

I know several people online are making really good money by interviewing experts, either in video format or on skype. I saw one guy at a recent marketing event who had turned up with a video camera and tripod, all set to interview the speakers at the event. The event cost him several hundred dollars to go to, but when he left he had to content that would pay him back the amount he had spent many times over.?This is an easy way to create content.

Video

You can use video to re-purpose content on the Internet, say for example articles from article directories. Start doing some research and compile some good information from articles and turn the content into video, a presentation perhaps where you take the viewer through strategies teaching them step-by-step. Show people ?how to do what they want to do? and you will make money.

PDF?s

The easiest way to do this would be to take a collection of articles from an article directory and just paste them into your report, (including the author details). Maybe you can add value by adding to the content and giving your take on things. This would be an excellent avenue for enticing people to sign up to a mailing list and you can do this so easily, all you need is an office suite like ?Open Office? and you can export the documents in PDF format.

Software

This is a personal favourite of mine and has enabled me to quit the rat race, although It?s not for everybody, as it takes quite a bit of technical know-how. However, you can easily to create your own software products using a development suite like Ubot Studio,

When I started I was using a free program called autohotkey?to develop software, I generated enough money with this free program (and I?m not a programmer) to enable me to purchase the developer license of Ubot studio and since purchasing the development suite my software has generated several hundred thousand dollars in revenue.

At the end of the day though the one thing that is going to make you money is ?FOCUS?, if you can?t stay focused on one project and see it through to completion,then you aren?t going to get anywhere. It?s a sad fact of life, but it?s true. I build and recommend products that make my life easier and the lives of my buyers, but if people don?t use them the way they were meant to be used, or they lose interest and jump onto the next ?big thing? then they will just stay stuck and will never progress.

?

Tagged with: info product creation ? information product creation

Filed under: affiliate marketing ? Internet And Businesses Online ? internet marketing ? Marketing ? Niche Marketing

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Source: http://stealthymarketer.co.uk/info-product-creation-tips/

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Saturday, March 30, 2013

Rising hopes about jobs propel consumer sentiment in March

Consumer sentiment jumped in the second half of March by a record amount as Americans discounted the effects of government spending cuts and saw more healing in the labor market, a survey released on Friday showed.

The Thomson Reuters/University of Michigan's final reading on the overall index on consumer sentiment came in at 78.6, up from 77.6 the month before.

That was well above the median forecast of 72.5 among economists polled by Reuters and a record upward revision from a preliminary reading of 71.8 in mid-March.

Analysts had fretted that the so-called sequester, a package of across-the-board government spending cuts of $85 billion that went into effect in early March, would drag on the economy and dampen sentiment.

But consumers seemed to have brushed those worries off, survey director Richard Curtin said in a statement, and the swell of sentiment in the second half of the month more than erased the decline of the first half of March.

"Consumers have discounted the administration's warning that economic catastrophe would follow the reductions in federal spending, and consumers have renewed their expectation that gains in employment will accelerate through the rest of 2013," he said.

"If the late March results are replicated in the months ahead, however, the economy may finally gain enough upward momentum to significantly reduce the unemployment rate."

The survey also saw the largest proportion of homeowners reporting recent increases in home values in more than five years, with gains expected by more homeowners than any time since the March 2007 survey.

The survey's barometer of current economic conditions rose to 90.7, its highest since January 2008. It was also up from February's 89.0 and above a forecast of 87.8.

The survey's gauge of consumer expectations rose to 70.8, revised up from a preliminary 61.7 and up from February's 70.2. Economists had forecast 62.0.

The survey's one-year inflation expectation fell to 3.2 percent from February's 3.3 percent, while the survey's five-to-10-year inflation outlook was at 2.8 percent versus 3.0 percent.

Copyright 2013 Thomson Reuters.

Source: http://feeds.nbcnews.com/c/35002/f/653351/s/2a22a89a/l/0L0Snbcnews0N0Cbusiness0Ceconomywatch0Crising0Ehopes0Eabout0Ejobs0Epropel0Econsumer0Esentiment0Emarch0E1C9140A0A0A4/story01.htm

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Haunted Hollow makes spooking competitive

Firaxis, best known for their work on the popular XCOM and Civilization games, are jumping into mobile with their first iPad title, Haunted Hollow. We checked it out at GDC 2013 with their publisher 2K, and it's shaping up to be really interesting. Two players face off at opposite ends of an unsuspecting village in large haunted mansions. Each player takes turns summoning monsters, sending them to the town, and scaring its hapless inhabitants. In the process, players gather fear points which are used to expand their mansion and create bigger baddies, and in turn control new neighborhoods of the village. Players also have to create some more aggressive monsters to fend off the opposing player's and the town's angry mob which invariably rises up against the haunted houses. The player which controls the whole town with fear wins.

Haunted Hollow is free to play, but players can pay to unlock new families of haunted houses, each with their own unique flavor and abilities. That set-up, along with the asynchronous multiplayer, reminded me an awful lot of Hero Academy, and that's generally a good thing. It helps that the game is very family-friendly, so you can pass-and-play in the living room.

Haunted Hollow is currently enjoying a soft launch in Canada, and expanding internationally this spring. Any takers?

Free - Download Now



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GWH News and Notes: Ric Flair's Son Found Dead at 25

GWH News and Notes: Ric Flair?s Son Found Dead at 25

Ric Flair?s Son Found Dead at 25


From Legacy Talent and Entertainment: "We are heartbroken to confirm that Ric's son, Reid Fliehr, has passed away today March 29, 2013 in Charlotte, NC. The investigation into the cause of death is ongoing. Reid was 25 and an incredible son, brother, friend, and professional wrestler. No words can describe the grief that Ric and his family are experiencing and they do request privacy during this devastating time."

Source: http://www.gwhnews.com/2013/03/ric-flairs-son-found-dead-at-25.html

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Friday, March 29, 2013

'Fairy circles' mysery solved? Tiny creators discovered.

'Fairy circles' dot deserts in southern Africa, but the mystery behind their origin may have been solved.

By Tanya Lewis,?Live Science / March 28, 2013

Oryx antelope tracks cross 'fairy circles' in Namibrand, Namibia.

N. Juergens / Live Science

Enlarge

The "artists" behind bizarre, barren, grassless rings dotting the desert of Southwest Africa have been found lurking right at scientists' feet: termites.

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Known as fairy circles, these patches crop up in regular patterns along a narrow strip of the Namib Desert between mid-Angola and northwestern South Africa, and can persist for decades. The cause of these desert pockmarks has been widely debated, but a species of sand termite, Psammotermes allocerus, could be behind the mysterious dirt rings, suggests a study published today (March 28) in the journal Science.

Scientists have offered many ideas about the circles' origin, ranging from "self-organizing vegetation dynamics" to carnivorous ants. Termites have been proposed before, but there wasn't much evidence to support that theory.

Finding patterns in circles

While studying the strange patterns, biologist Norbert Juergens of the University of Hamburg noticed that wherever he found the dirt patches (the barren centers inside fairy circles), he also found sand termites. [See Photos of the Bizarre Fairy Circles]

Juergens measured the water content of the soil in the circles from 2006 to 2012. More than 2 inches (5 centimeters) of water was stored in the top 39 inches (100 cm) of soil, even during the driest period of the year, Juergens found. The soil humidity below about 16 inches (40 cm) was 5 percent or more over a four-year stretch.

Without grass to?absorb rainwater and then release it back into the air via evaporation, any water available would collect in the porous, sandy soil, Juergens proposed. That water supply could be enough to keep the termites alive and active during the harsh dry season, while letting the grass survive at the circles' rims.

Juergens conducted surveys of the organisms found at fairy circles. The sand termite was the only creature he found consistently at the majority of patches. He also discovered that most patches contained layers of cemented sand, foraged plant material and underground tunnels ? telltale signs of sand termites.

?The scientist found a few other termite species, as well as three ant species, at fairy circles in areas that get rain during the summer or during the winter, but not at all the sites he studied.

Teensy engineers

Source: http://rss.csmonitor.com/~r/feeds/science/~3/OEsoWR2ilgI/Fairy-circles-mysery-solved-Tiny-creators-discovered

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'My Girl' Star Anna Chlumsky Is Pregnant!

Anna Chlumsky is having a baby! Plus, see more stars who are expecting.

Source: http://www.ivillage.com/pregnant-celebrity-photos-look-whos-popping/1-b-18178?dst=iv%3AiVillage%3Apregnant-celebrity-photos-look-whos-popping-18178

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Appeals court revives lawsuit against Justice Dept

WASHINGTON (AP) ? A federal appeals court on Friday revived part of a lawsuit by two attorneys who applied for prestigious Justice Department jobs during the George W. Bush administration and alleged they were denied interviews because of their liberal political views.

The department destroyed files on the lawyers' applications to be hired under the department's Honors Program. Government lawyers said they did so for lack of storage space.

However, the appeals court ruled that, while the Privacy Act bars agencies from keeping records about an individual's exercise of free speech, senior Justice Department officials should have preserved the documents because an investigation and lawsuits were foreseeable.

The applicants argued that a lower court judge ignored relevant evidence in dismissing their suit, including the fact that a screening committee comprised of two Bush administration political appointees conducted internet searches about applicants' political leanings.

Although they revived the lawsuit, the three-member panel of judges from the U.S. Circuit Court of Appeals for the District of Columbia refused to make the case a class action on behalf of all applicants who might have been denied interviews because of liberal political affiliations.

In her opinion for the appeals court, Circuit Judge Judith Rogers said the Justice Department had a duty to preserve the records. The fact that it did not, she concluded, supports the inference the department engaged in "spoliation," which means intentional or negligent withholding of evidence relevant to a legal proceeding.

The appellate court explicitly ordered the District Court, when it tries the case, to adopt that negative inference. The higher court said that would permit a reasonable trial court and jury to find that the two applicants were harmed by creation and use of the destroyed records.

Rogers is an appointee of President Bill Clinton. The other two appeals judges in the case are chief judge Merrick Garland, a Clinton appointee, and Thomas Griffith, an appointee of George W. Bush.

The Attorney General Honors Program is the largest and most prestigious federal entry-level attorney hiring program. Selections are made based on a demonstrated commitment to government service, academic achievement, leadership, law review experience, legal aid and clinical experience, past employment, and extracurricular activities.

"Unrebutted evidence demonstrates that department officials in control of the printed, annotated applications were on notice that department investigation and future litigation concerning the 2006 Honors Program improprieties were reasonably foreseeable," Rogers wrote. "Nevertheless, they intentionally destroyed these records."

Rogers said the director of the recruitment management office received complaints from high-ranking department officials and other employees about the handling of the 2006 attorney hiring process and were aware of the perception that it had been politicized.

Rogers said one of the Bush administration political appointees on the screening committee, Esther McDonald, conducted Internet searches to learn the ideological affiliations of applicants. A search of McDonald's computer hard drive revealed she had found that one of the attorneys, who later brought this lawsuit, had opposed the presence of military recruiters on Cornell University's campus and that another had been elected to a seat on the City Council of La Crosse, Wis., as a member of the Green Party. That information was not contained in the applications submitted by the attorneys.

Widespread criticism of the management of the Honors Program arose inside the Justice Department after the screening committee "deselected" an unusually high number of applicants who had already been invited to travel to Washington for interviews.

A Justice Department inspector general's report later found that the screening committee deselected 40 percent of highly qualified applicants with liberal affiliations and only 6 percent of highly qualified applicants with conservative affiliations.

"This decision should stand as a potent deterrent to any such high-level corruption for years to come," said attorney Dan Metcalfe, a former longtime freedom of information official at the Justice Department who represented the two applicants.

Source: http://news.yahoo.com/appeals-court-revives-lawsuit-against-justice-dept-151139094--politics.html

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Send Us Photos of Your Beautifully Cracked Smartphone Screens

Send Us Photos of Your Beautifully Cracked Smartphone Screens
Wired wants to see your artsy photos of a smartphone or tablet with a busted screen. Cracks, chips, complete obliteration -- if it's broken, we're interested. We'll gather the best photos and present them here for all to enjoy.

Source: http://feedproxy.google.com/~r/GearFactor/~3/H69oMZoCbtc/

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Thursday, March 28, 2013

Google Translate app updated with offline support

Google Translate offline

An update to the Google Translate app for Android is going out today, adding support for offline translations for fifty languages. It's a big upgrade for Google Translate, which until now has required an internet connection. (We all know how expensive international roaming can be.)

The new version supports Android 2.3 Gingerbread and above, and languages can be downloaded from the new "Offline languages" menu. A word of warning -- downloading an entire language to your phone takes just as much space as you'd imagine. With only English and German installed, we'd already taken up a hefty 280MB of internal storage.

There are also some limitations to offline mode -- it's currently text-only, so voice translation and image translation don't work offline.

If you've already got Google Translate installed, hit the Play Store to get the latest update. If not, you can use the handy Google Play link above.

Source: Google



Source: http://feedproxy.google.com/~r/androidcentral/~3/Z2Sow0EHwgI/story01.htm

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Virtual games help the blind navigate unknown territory

Mar. 27, 2013 ? On March 27thJoVE (Journal of Visualized Experiments) will publish a new video article by Dr. Lotfi Merabet showing how researchers in the Department of Ophthalmology at Massachusetts Eye and Ear Infirmary and Harvard Medical School have developed a virtual gaming environment to help blind individuals improve navigation skills and develop a cognitive spatial map of unfamiliar buildings and public locations.

"For the blind, finding your way or navigating in a place that is unfamiliar presents a real challenge," Dr. Merabet explains. "As people with sight, we can capture sensory information through our eyes about our surroundings. For the blind that is a real challenge? the blind will typically use auditory and tactile cues."

The technique utilizes computer generated layouts of public buildings and spatial sensory feedback to synthesize a virtual world that mimics a real world navigation task. In the game, participants must find jewels and carry them out of the building, without being intercepted by roaming monsters that steal the jewels and hide them elsewhere.

Participants interface with the virtual building by using a keyboard and wearing headphones that play auditory cues that help spatially orient them to the world around them. This interaction helps users generate an accurate mental layout of the mimicked building. Dr. Merabet and his colleagues are also exploring applications of this technology with other user interfaces, like a Wii Remote or joystick.

"We have developed software called ABES, the Audio Based Environment Simulator that represents the actual physical environment of the Carol Center for the Blind in Newton Massachusetts. The participants will use the game metaphor to get a sense of the whole building through open discovery, allowing people to learn room layouts more naturally than if they were just following directions."

The technology will invariably be useful for the 285 million blind people world-wide, 6 million of which live in the United States. It will also have applications beyond the blind community for individuals with other visual impairments, cognitive deficits, or those recovering from brain injuries.

Dr. Merabet considers publication in JoVE's video format especially helpful. "It is conceptually difficult for a sighted person to understand 'a video game for blind people.' What JoVE allows us to do is break down layouts of the game and strategy, show how the auditory cues can be used and how we quantify performance going from the virtual game to the physical world."

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Story Source:

The above story is reprinted from materials provided by Journal of Visualized Experiments.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Erin C. Connors, Lindsay A. Yazzolino, Jaime S?nchez, Lotfi B. Merabet. Development of an Audio-based Virtual Gaming Environment to Assist with Navigation Skills in the Blind. Journal of Visualized Experiments, 2013; (73) DOI: 10.3791/50272

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_technology/~3/PWTGJ6zp7M8/130327102648.htm

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Expensify Now Offers Support For Bitcoin, An Alternative To PayPal For International Contractors

Image (1) expensifylogo.png for post 129193Expensify is now supporting Bitcoin to give international contractors an alternative to Paypal and the high fees associated with the service.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/pPUzoW8CQJA/

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Wednesday, March 27, 2013

Researchers discover the brain origins of variation in pathological anxiety

Tuesday, March 26, 2013

New findings from nonhuman primates suggest that an overactive core circuit in the brain, and its interaction with other specialized circuits, accounts for the variability in symptoms shown by patients with severe anxiety. In a brain-imaging study to be published online today in the Proceedings of the National Academy of Sciences (PNAS), researchers from the University of Wisconsin School of Medicine and Public Health describe work that for the first time provides an understanding of the root causes of clinical variability in anxiety disorders.

Using a well-established nonhuman primate model of childhood anxiety, the scientists identified a core circuit that is chronically over-active in all anxious individuals, regardless of their particular pattern of symptoms. They also identified a set of more specialized circuits that are over- or under-active in individuals prone to particular symptoms, such as chronically high levels of the stress-hormone cortisol.

"These findings provide important new insights into altered brain functioning that explain why people with anxiety have such different symptoms and clinical presentations, and it also gives us new ideas, based on an understanding of altered brain function, for helping people with different types of anxiety,'' says Dr. Ned Kalin, senior author, chair of Psychiatry and director of the HealthEmotions Research Institute.

"There is a large need for new treatment strategies, because our current treatments don't work well for many anxious adults and children who come to us for help."

In the study, key anxiety-related symptoms were measured in 238 young rhesus monkeys using behavioral and hormonal measurement procedures similar to those routinely used to assess extreme shyness in children. Young monkeys are ideally suited for these studies because of their similarities in brain development and social behavior, Kalin noted. Variation in brain activity was quantified in the monkeys using positron emission tomography (PET) imaging, a method that is also used in humans.

Combining behavioral measures of shyness, physiological measures of the stress-hormone cortisol, and brain metabolic imaging, co-lead authors Dr. Alexander Shackman, Andrew Fox, and their collaborators showed that a core neural system marked by elevated activity in the central nucleus of the amygdala was a consistent brain signature shared by young monkeys with chronically high levels of anxiety. This was true despite striking differences across monkeys in the predominance of particular anxiety-related symptoms.

The Wisconsin researchers also showed that young monkeys with particular anxiety profiles, such as high levels of shyness, showed changes in symptom-specific brain circuits. Finally, Shackman, Fox, and colleagues uncovered evidence that the two kinds of brain circuits, one shared by all anxious individuals, the other specific to those with particular symptoms, work together to produce different presentations of pathological anxiety.

The new study builds upon earlier work by the Kalin laboratory demonstrating that activity in the amygdala is strongly shaped by early-life experiences, such as parenting and social interactions. They hypothesize that extreme anxiety stems from problems with the normal maturation of brain systems involved in emotional learning, which suggests that anxious children have difficulty learning to effectively regulate brain anxiety circuits. Taken together, this line of research sets the stage for improved strategies for preventing extreme childhood anxiety from blossoming into full-blown anxiety disorders.

"This means the amygdala is an extremely attractive target for new, broad-spectrum anxiety treatments,'' says Shackman. "The central nucleus of the amygdala is a uniquely malleable substrate for anxiety, one that can help to trigger a wide range of symptoms."

The work also suggests more specific brain targets for different symptom profiles. Such therapies could range from new, more selectively targeted medications to intensive therapies that seek to re-train the amygdala, ranging from conventional cognitive-behavioral therapies to training in mindfulness and other techniques, Shackman noted. To further understand the clinical significance of these observations, the laboratory is conducting a parallel study in young children suffering from anxiety disorders.

###

University of Wisconsin-Madison: http://www.wisc.edu

Thanks to University of Wisconsin-Madison for this article.

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Source: http://www.labspaces.net/127463/Researchers_discover_the_brain_origins_of_variation_in_pathological_anxiety

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Fruit flies fed organic diets are healthier than flies fed nonorganic diets

Mar. 26, 2013 ? A new study looking at the potential health benefits of organic versus non-organic food found that fruit flies fed an organic diet recorded better health outcomes than flies fed a nonorganic diet.

The study from the lab of SMU biologist Johannes H. Bauer, Southern Methodist University, Dallas, found that fruit flies raised on diets of organic foods performed better on several tests for general health.

"While these findings are certainly intriguing, what we now need to determine is why the flies on the organic diets did better, especially since not all the organic diets we tested provided the same positive health outcomes," said Bauer, principal investigator for the study.

Fruit flies on organic diets showed improvements on the most significant measures of health, namely fertility and longevity, said high school student researcher Ria Chhabra.

"We don't know why the flies on the organic diet did better. That will require further research. But this is a start toward understanding potential health benefits," said Chhabra, a student at Clark High School in Plano, Texas, who led the experiment.

Chhabra sought to conduct the experiments after hearing her parents discuss whether it's worth it to buy organic foods to achieve possible health benefits.

Bauer, an assistant professor in SMU's Department of Biological Sciences, mentored Chhabra by helping guide and design her research experiments. The research focus of Bauer's fruit fly lab is nutrition and its relationship to longevity, health and diabetes.

"It's rare for a high school student to have such a prominent position in the lab. But Ria has tremendous energy and curiosity, and that convinced me to give this research project a try," Bauer said.

The findings, "Organically grown food provides health benefits to Drosophila melanogaster," have been published in the open access journal PLOS One. Buaer and Chhabra co-authored the paper with Santharam Kolli, a research associate at SMU.

Flies on organic food performed better on some health tests

"The data demonstrated that flies raised on organic food extracts by-and-large performed better on the majority of health tests," reported the researchers.

It remains unclear why organic diets delivered better health, the researchers said.

The Bauer lab results come at a time when the health effects of organic food are widely debated.

Prior studies by other researchers have found conflicting results when reviewing the scientific literature for data. While several studies have shown elevated nutrient content and lower pesticide contamination levels in organic food, a recent publication reporting a large-scale analysis of all available studies concluded no clear trend was apparent.

Fruit flies were fed extracts from produce purchased at a grocery store

In order to investigate whether organic foods are healthier for consumers, the lab utilized one of the most widely used model systems, the fruit fly Drosophila melanogaster. Because of the low costs associated with fly research and the fly's short life cycle, researchers use fruit flies to study human diseases, from diabetes to heart function to Alzheimer's disease.

The Bauer lab fruit flies were fed organic and nonorganic produce purchased from a leading national grocery retailer of organic and conventional foods. The flies were fed extracts made from organic and conventional potatoes, soybeans, raisins and bananas. They were not fed any additional nutritional supplements. The researchers tested the effects of each food type independently and avoided any confounding effects of a mixed diet.

The health tests measured longevity, fertility, stress and starvation resistance.

Findings suggest beneficial health effects dependent on specific foods

Some negative or neutral results were obtained using diets prepared from organic raisins, which suggests the beneficial health effects of organic diets are dependent on the specific food item, Bauer said. That might explain some of the inconsistent results in the published studies in the scientific literature, he said, noting some studies suggest there is a nutritional benefit from organic food, while others suggest there is not.

"To our surprise, in the majority of our tests of flies on organic foods, the flies fed organic diets did much better on our health tests than the flies fed conventional food," Bauer said. "Longevity and fertility are the two most important aspects of fly life. On both of these tests, flies fed organic diets performed much better than flies fed conventional diets. They lived longer, had higher fertility, and had a much higher lifetime reproductive output."

Factors such as soil condition and latitude where the produce was grown weren't considered, mimicking a typical grocery store shopping experience.?

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The above story is reprinted from materials provided by Southern Methodist University. The original article was written by Margaret Allen.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Ria Chhabra, Santharam Kolli, Johannes H. Bauer. Organically Grown Food Provides Health Benefits to Drosophila melanogaster. PLoS ONE, 2013; 8 (1): e52988 DOI: 10.1371/journal.pone.0052988

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/living_well/~3/xdeiKpzalhY/130326121732.htm

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Tuesday, March 26, 2013

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Source: http://midtownlunch.com/forums/topic/netherlands-international-bureau-of-fiscal-documentation

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Clean electricity from bacteria? Researchers make breakthrough in race to create 'bio-batteries'

Mar. 25, 2013 ? Scientists at the University of East Anglia have made an important breakthrough in the quest to generate clean electricity from bacteria.

Findings published today in the journal Proceedings of the National Academy of Sciences (PNAS) show that proteins on the surface of bacteria can produce an electric current by simply touching a mineral surface.

The research shows that it is possible for bacteria to lie directly on the surface of a metal or mineral and transfer electrical charge through their cell membranes. This means that it is possible to 'tether' bacteria directly to electrodes -- bringing scientists a step closer to creating efficient microbial fuel cells or 'bio-batteries'.

The team collaborated with researchers at Pacific Northwest National Laboratory in Washington State in the US.?

Shewanella oneidensis is part of a family of marine bacteria. The research team created a synthetic version of this bacteria using just the proteins thought to shuttle the electrons from the inside of the microbe to the rock.

They inserted these proteins into the lipid layers of vesicles, which are small capsules of lipid membranes such as the ones that make up a bacterial membrane. Then they tested how well electrons travelled between an electron donor on the inside and an iron-bearing mineral on the outside.

Lead researcher Dr Tom Clarke from UEA's school of Biological Sciences said: "We knew that bacteria can transfer electricity into metals and minerals, and that the interaction depends on special proteins on the surface of the bacteria. But it was not been clear whether these proteins do this directly or indirectly though an unknown mediator in the environment.

"Our research shows that these proteins can directly 'touch' the mineral surface and produce an electric current, meaning that is possible for the bacteria to lie on the surface of a metal or mineral and conduct electricity through their cell membranes.

"This is the first time that we have been able to actually look at how the components of a bacterial cell membrane are able to interact with different substances, and understand how differences in metal and mineral interactions can occur on the surface of a cell.

"These bacteria show great potential as microbial fuel cells, where electricity can be generated from the breakdown of domestic or agricultural waste products.

"Another possibility is to use these bacteria as miniature factories on the surface of an electrode, where chemicals reactions take place inside the cell using electrical power supplied by the electrode through these proteins."

Biochemist Liang Shi of Pacific Northwest National Laboratory said: "We developed a unique system so we could mimic electron transfer like it happens in cells. The electron transfer rate we measured was unbelievably fast -- it was fast enough to support bacterial respiration."

The finding is also important for understanding how carbon works its way through the atmosphere, land and oceans.

"When organic matter is involved in reducing iron, it releases carbon dioxide and water. And when iron is used as an energy source, bacteria incorporate carbon dioxide into food. If we understand electron transfer, we can learn how bacteria controls the carbon cycle," said Shi.

The project was funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and the US Department of Energy.

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Story Source:

The above story is reprinted from materials provided by University of East Anglia.

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Journal Reference:

  1. Thomas A Clarke, Gaye White, Julea N Butt, David J Richardson, Zhri Shi, Liang Shi, Zheming Wang, Alice C Dohnalkova, Matthew J Marshall, James K Fredrickson and John M Zachara. Rapid electron exchange between surface-exposed bacterial cytochromes and Fe(III) minerals. Proceedings of the National Academy of Sciences, March 25, 2013

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/matter_energy/biochemistry/~3/C9b9oM-guKU/130325183900.htm

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University of California course work: LGBTQ views of pop music

University of California students needing a quick music course to fill out their credit requirements for graduation have an option this summer: Take the ?Lesbian, Gay, Bisexual, Transgender and Queer Perspectives in Pop Music? class.

Campus Reform reports that class is a weekly ?survey of English-language popular music in the 20th century, with focus on lesbians, gay men and members of other sexual minorities as creators, performers and audience members.? The cost of the course: It?s $1,395 for U.C. students and $2,085 for non-U.C. students, and at least 55 have already signed up, Campus Reform reports.

It?s part of the UCLA?s Lesbian, Gay, Bisexual and Transgender Studies Department, which has already offered classes like, ?Chicana Lesbian Literature,? and ?Psychology of the Lesbian Experience,? Campus Reform reports.

The LGBT agenda isn?t confined to California schools.

The University of Tennessee is going to spend $20,000 from a student fund on a ?sex week? that will include a ?Golden Condom Scavenger Hunt? as well as an ?interactive workshop ? [from] lesbian Bondage, Discipline, Sadism and Masochism expert? Sinclair Sexsmith, Campus Reform reports.

The sex week starts on April 7.

? Copyright 2013 The Washington Times, LLC. Click here for reprint permission.

Source: http://www.washingtontimes.com/news/2013/mar/25/university-california-course-work-lgbtq-views-pop-/?utm_source=RSS_Feed&utm_medium=RSS

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Monday, March 25, 2013

Mars rover back in action after computer problems

File - An undated file image released by NASA shows a self-portrait of NASA?s Mars rover Curiosity. After back-to-back computer problems, the six-wheel rover has resumed its science experiments. (AP Photo/NASA)

File - An undated file image released by NASA shows a self-portrait of NASA?s Mars rover Curiosity. After back-to-back computer problems, the six-wheel rover has resumed its science experiments. (AP Photo/NASA)

(AP) ? The Mars rover Curiosity is humming again after being sidelined by back-to-back computer problems.

The six-wheel rover fired up its onboard laboratories and analyzed a pinch of rock dust over the weekend. It had been unable to perform science experiments since late last month after experiencing a computer memory problem.

Mission managers say Curiosity will work for a week before it takes another break. But this one is planned, because the sun will block communications between Earth and Mars.

Before the computer woes, Curiosity drilled into a rock, tested the powder and found it contained some of the chemical ingredients necessary for microbial life. There are plans to drill into another rock before setting off for a mountain later this year.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/b2f0ca3a594644ee9e50a8ec4ce2d6de/Article_2013-03-25-Mars%20Curiosity/id-9f05a218261a477397b4e8b7fe01601a

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Building the Impact Investing Space in Latin America | CASE Notes

This post was written by Karina Pena of the Americas Society / Council of the Americas (AS/COA).? Read the original post on their website.

On March 6, AS/COA held an expert panel on impact investing and social entrepreneurship in Latin America. Discussion focused on the differences between impact investing and philanthropy, the role of risk in these investments, and how to build the impact investing ecosystem.

Impact Investing vs. Philanthropy

The first question panelists discussed was the definition of impact investing. The Global Impact Investing Network describes these as ?investments made into companies, organizations, and funds with the intention to generate measurable social and environmental impact alongside a financial return.??Ben Wirz of the Knight Foundation offered a definition of his own, saying it?s ?when you?re making an investment and you?re taking an extra degree of risk because you want a social return.? Risk, Wirz said, is greater when prioritizing social impact over profit. Catherine Clark of Duke University argued impact investors would not unanimously agree that impact is characterized by taking on additional risk and concessionary financial returns. Jocelyn Cortez-Young of Minerva Capital added that impact investing is more sustainable than philanthropy due to earned profit. Nacho Gonz?lez of SociaLab.com sought to reconcile these views by suggesting that impact investing is an evolved, more sustainable form of philanthropy due to its foundation in business practices.

Cortez-Young stressed that the key to a successful impact investment is in finding a feasible solution to a real problem that may be overlooked. Gonz?lez added that innovation in Latin America is different than in the United States?the areas with the most untapped potential can be found in emerging markets where because of the internet, previously unreachable populations are now accessible. The key to the next big idea is finding a solution that provides social benefits to a broader population, Gonz?lez said.

Risk: The Unknown for Impact Investors

Speakers noted that because of increased risk, it can prove a challenge to sell impact investments to traditional, profit-driven investors. Given that impact investing is in a relatively early stage, the space lacks risk metrics sought by traditional investors. By virtue of its socially oriented nature, it is difficult to predict quantifiable returns on investment, and few IPOs have been completed as a reference point. Still, there are ways to pitch these ventures successfully, and Clark noted an increase in angel investors and investment groups looking at the space. Cortez-Young referred to derivatives as an example of investment with a reduced percentage of risk, involving a fixed-income note plus a call option. The call option is an opportunity to invest in something unknown based on the known performance of the note?providing the investor less risk. Cortez-Young argued that the impact investing sphere can learn from derivatives, in that more investors could be attracted to this space if at least a certain percentage of risk can be ascertained.

Speakers also discussed the importance of creating a thorough business proposal. Before presenting a pitch to a traditional investor, one should look into the investor?s areas of interest?such as housing, education, agriculture, and access to technology?and see if these issues can addressed. As Wirz noted, one should also speak in the investor?s own terms, which can be difficult but crucial in securing funding. Cortez-Young explained that a pitch must stress which investments open up sources beyond philanthropy dollars, and move toward endowments and pension funds that seek financial returns.

Building the Impact Investing Ecosystem

Panelists noted the importance of fostering an impact investing ecosystem in Latin America. Currently, private foundations, private banks, development agencies, and private impact investing funds are participating in impact investing. But only a small portion of the $7.9 billion in private equity and venture capital investments in Latin America last year was allocated to impact investing. Co-investing among sectors presents another strategic opportunity for the young impact investing scene, Clark said. She noted that by ?stacking? capital, one can make several deals with different investors at varying levels of capital, thereby securing funding at different stages of an enterprise. Cortez-Young added that a cyclical trend in impact investing has emerged: many recipients of successful Minerva Capital investments tend to go on and invest their own money in other ventures.

View the panel video and full post on AS/COA?s website.

Source: http://blogs.fuqua.duke.edu/casenotes/2013/03/25/building-the-impact-investing-space-in-latin-america/

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Kerry wants Iraq to stop arms shipments to Syria. Why would Iraq agree?

A sharp divergence in Iraqi and US interests was on display in Secretary of State John Kerry's surprise visit to Baghdad.

By Dan Murphy,?Staff writer / March 24, 2013

Secretary of State John Kerry speaks to the media aboard an Air Force C-130 on his way back from Baghdad, Iraq on Sunday. Kerry is calling for Iraq to stop sending arms to Syria.

Jason Reed/AP

Enlarge

US Secretary of State John Kerry made a previously unannounced stop in Baghdad today, and in the process unintentionally highlighted the difficult job he's been assigned in advancing the US diplomatic agenda as regards to the Syrian civil war.

Skip to next paragraph Dan Murphy

Staff writer

Dan Murphy is a staff writer for the Monitor's international desk, focused on the Middle East.?Murphy, who has reported from Iraq, Afghanistan, Egypt, and more than a dozen other countries, writes and edits Backchannels. The focus? War and international relations, leaning toward things Middle East.

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The US would like to see the government of Syria's Bashar al-Assad fall, and has been expanding "non-lethal" support towards that objective even as Saudi Arabia and other Gulf States have been arming the rebels.

But Iraq is on the other side of the equation. After the removal of Saddam Hussein's regime, a Shiite-Islamist government came to power in the country, with better current relations with the Islamic Republic of Iran than with the US. With Iran backing Mr. Assad, and the likelihood of Sunni Islamists coming to power if Assad falls, Iraq's interests and America's are sharply divergent.

The people fighting Assad look to Iraqi Prime Minister Nouri al-Maliki very similar to the Sunni forces, many jihadi, that vehemently oppose his government and continue to carry out mass casualty suicide bombings in Iraq. Al Qaeda in Iraq has already been working with some of the salafi rebel groups in Syria like the Jabhat al-Nusra (ironically on the US State Department's list of terrorist organizations) and their dream would be to have a new friend across the border when the dust settles in Syria, arming and supporting them in their unlikely quest to restore Sunni Arab hegemony in Iraq. ?

What's more, Iraq has oil. Lots of it. While it also has enormous social problems Iraq already has a fairly well-armed and capable military (Note: May have this wrong; knowledgeable folks on Twitter heavily dispute this and will do more research). There is very little Mr. Maliki needs from the US anymore (one of the reasons he, essentially, kicked US troops out of the country at the end of 2011).

So that's the context in which Mr. Kerry arrived in Baghdad today to jawbone Maliki over tacit support for Assad. Kerry told reporters after he met Maliki that the US would like to see that support end, particularly allowing Iran to fly through Iraqi airspace to help arm and supply the Syrian military. The US also alleges that arms-shipments are being trucked through Iraq from Iran to aid Assad.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/Dv-6rns3yMs/Kerry-wants-Iraq-to-stop-arms-shipments-to-Syria.-Why-would-Iraq-agree

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Northern Irish police defuse car bomb near G8 venue

BELFAST (Reuters) - Northern Irish police defused a bomb in a car on Saturday close to where G8 leaders will meet at a summit in June and said that the device was likely to have been intended for a police station nearby.

Army bomb disposal experts defused the device after a security operation that lasted almost 36 hours in the county Fermanagh town of Enniskillen. The Group of Eight leaders meet just outside the town in three months' time.

A senior Northern Irish officer said police believed the bomb was en route to a police station in a town nearby and would have killed or injured people if it had not been intercepted.

"Once again our community has been disrupted and the lives of residents put at risk by an element intent on causing loss of life and disruption," District Commander Pauline Shields said in a statement.

"The people responsible for this have no regard for the lives of anyone in our community. It is fortunate that no-one was killed or seriously injured as a result of this reckless act."

A 1998 peace deal largely ended more than three decades of violence in the British-controlled province between mainly Catholic Irish nationalists seeking union with Ireland and predominantly Protestant unionists who want to remain part of the United Kingdom.

However militant nationalists, who include former operatives who split from the Irish Republican Army (IRA) after it declared a ceasefire, still stage sporadic gun and bomb attacks and have targeted security forces in particular.

An attempt to fire mortar bombs at a police station was foiled earlier this month in what would have been the first attack of its kind in the United Kingdom since the peace deal ended the IRA's campaign of violence.

(Reporting by Ian Graham; Editing by Padraic Halpin and Michael Roddy)

Source: http://news.yahoo.com/northern-irish-police-defuse-car-bomb-near-g8-140147653.html

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